Search ↗

Clinics · Comparison

OneTwenty vs SiPhox Health

Both are primarily bloodwork & longevity providers, so the differences are in consult model, what is bundled, who prescribes, and price.

OneTwenty logo OneTwenty From $499/yr membership Read the OneTwenty review →
vs
SiPhox Health From $124 per at-home test kit Read the SiPhox Health review →

Side-by-side comparison

OneTwenty logoOneTwentySiPhox Health
Our score9.9 / 109.0 / 10
Starting price$499/yr membership$124 per at-home test kit
Primary serviceBloodwork & longevityBloodwork & longevity
All servicesBloodwork, TRT, GLP-1, PeptidesBloodwork
Consult modelUnconfirmedUnconfirmed
PrescriberUnconfirmedUnconfirmed
LabsIncludedIncluded
InsuranceCash payCash pay
Availability49 states49 states
CancellationSelf-serve onlineSelf-serve online
Trustpilot—4.7 / 5 (1,181 reviews)
Regulatory / legal recordNone foundNone found
Visit ↗Visit ↗

* Provisional score: one or two criteria could not be verified.

Which one is right for you

Choose OneTwenty if…

People who want their blood retested every 90 days (a 101-marker baseline plus three follow-up panels a year) and want custom supplements and prescriptions, at published prices, driven by those results in one membership.

  • Four lab panels a year (101-marker baseline plus three 20 to 40 marker follow-ups) are included in the membership price
  • Membership and every available medication have a published monthly price: $499/yr ($749/yr in NY/NJ), medications $49 to $279/mo
  • Lists 49 states (all but Rhode Island)

Choose SiPhox Health if…

People who want frequent, needle-free at-home tracking of a focused biomarker panel and do not need a clinician or prescriptions from the same service.

  • Each plan period includes an at-home test kit; no lab visit or needle draw
  • Self-serve cancellation in the account portal with no minimum commitment
  • Choice of testing cadence (monthly, quarterly or every 6 months) and free switching between four core panels

Price: what you actually pay

OneTwenty

Pricing page (seen 2026-11-05; the page says its prices were checked on 2 November 2026): $499 a year, billed annually, for four lab panels: a 101-marker baseline (OneTwenty's own count) plus three follow-up panels of 20 to 40 markers, one every 90 days ('161 to 221 lab results a year'). Walk-in draws at Quest are included; an at-home draw is $99 per draw. NY and NJ: $749 a year because Quest cannot be used there. Add-ons: custom supplement packs from $45/mo; extra lab panels 'at cost' (no prices listed). Medications are priced per product on each treatment page: metformin and sildenafil $49/mo, tadalafil $79/mo, GHK-Cu cream and testosterone cypionate $99/mo, enclomiphene, glutathione (injection or nasal) and oxytocin $129/mo, sermorelin and NAD+ (injection or nasal) $149/mo, compounded semaglutide $179/mo, PT-141 $199/mo, tirzepatide $279/mo or $749 billed quarterly. Whether a separate provider consultation fee applies is not stated. The 'Founding pricing ends at public launch' line seen on 2026-10-17 no longer appears on the homepage or pricing page, but the What We Test page still says 'Now accepting founding members'.

SiPhox Health

Homepage (seen 2026-11-05): 'Start testing $124 + Shipping & handling'; 'No monthly fees'; the plan renews on the cadence chosen (monthly, quarterly or every 6 months) and includes the test kit with a choice of four core panels (Longevity Essentials, Thyroid Focus, Hormone Focus, Heart & Metabolic; 25 to 28 biomarkers per test, upgradeable to 59), results dashboard, action plan and AI assistant. Upgrades per test: Ultimate 360 (60 biomarkers) +$125; GLP Optimization panel +$75; IGF-1 add-on +$70. Shipping and handling amount is not stated on the pages loaded. Product data embedded in the pricing page lists the Longevity Essentials kit at $125 per period and a one-time panel at $225; those figures are not displayed as text.

What happens after you sign up

OneTwenty

Treatments offered: Enclomiphene, Compounded semaglutide, Tirzepatide, Sermorelin, Sildenafil, Tadalafil, PT-141 (bremelanotide), Oxytocin nasal spray, Metformin, NAD+ (injection and nasal spray), Glutathione (injection and nasal spray), GHK-Cu cream, Testosterone cypionate.

SiPhox Health

Testing and insights only. No prescriptions.

Cancelling and refunds

OneTwenty

Payment and Refund Policy (updated 2026-07-28): cancel via the option in account settings or by emailing support@onetwenty.com. The annual membership renews automatically. A refund is available only within 7 days of purchase and only if no service has started, minus a 3% fee. After that the annual fee is non-refundable, except for a discretionary prorated refund if no lab is reachable. Medication add-ons are non-refundable once prescribed.

SiPhox Health

FAQ: modify, pause or cancel 'anytime from your account portal. There's no commitment'; prepaid annual plans stop renewing at the end of the period. Terms of Service (last updated 2026-06-15): subscriptions auto-renew until cancelled via the 'Manage Membership' page in Account Settings or by emailing support@siphoxhealth.com. Refund Policy (updated 2026-02-02): no refunds for a period in which a kit has already shipped; to cancel a pending shipment, email support; monthly payments are nonrefundable and benefits continue to the end of the paid period. Kits cannot be returned.

Where each is available

OneTwenty

Site FAQ: 'available in 49 states except for Rhode Island'; NY and NJ carry a higher fee ($749/yr) because of state lab-draw rules. DC not mentioned.

SiPhox Health

State Coverage page: 'We do not yet provide services in: Hawaii and New York.' Diagnostic kits are offered everywhere else, including DC (48 states + DC). Telemedicine services are excluded in Alaska, Delaware, DC, Hawaii, Kansas, Louisiana, Mississippi and New York. Also offered in Canada without telemedicine.

Full breakdown of each

#1 OneTwenty logo

People who want their blood retested every 90 days (a 101-marker baseline plus three follow-up panels a year) and want custom supplements and prescriptions, at published prices, driven by those results in one membership.

Starting price
$499/yr membership
Consult model
Unconfirmed
Prescriber
Unconfirmed
Labs
Included
Insurance
Cash pay
Availability
49 states
Cancellation
Self-serve online
Founded
Unconfirmed

Pricing

Pricing page (seen 2026-11-05; the page says its prices were checked on 2 November 2026): $499 a year, billed annually, for four lab panels: a 101-marker baseline (OneTwenty's own count) plus three follow-up panels of 20 to 40 markers, one every 90 days ('161 to 221 lab results a year'). Walk-in draws at Quest are included; an at-home draw is $99 per draw. NY and NJ: $749 a year because Quest cannot be used there. Add-ons: custom supplement packs from $45/mo; extra lab panels 'at cost' (no prices listed). Medications are priced per product on each treatment page: metformin and sildenafil $49/mo, tadalafil $79/mo, GHK-Cu cream and testosterone cypionate $99/mo, enclomiphene, glutathione (injection or nasal) and oxytocin $129/mo, sermorelin and NAD+ (injection or nasal) $149/mo, compounded semaglutide $179/mo, PT-141 $199/mo, tirzepatide $279/mo or $749 billed quarterly. Whether a separate provider consultation fee applies is not stated. The 'Founding pricing ends at public launch' line seen on 2026-10-17 no longer appears on the homepage or pricing page, but the What We Test page still says 'Now accepting founding members'.

Prices as listed on November 5, 2026. They change often; confirm at checkout.

What we like

  • Four lab panels a year (101-marker baseline plus three 20 to 40 marker follow-ups) are included in the membership price
  • Membership and every available medication have a published monthly price: $499/yr ($749/yr in NY/NJ), medications $49 to $279/mo
  • Lists 49 states (all but Rhode Island)

Watch out for

  • The annual membership is non-refundable after a 7-day window, and only if no service has started (3% fee applies)
  • Not a medical practice: prescriptions come from unnamed third-party telehealth providers, and the site does not say whether they are physicians or NPs or whether visits are by video
  • Early-stage company: it opened a closed beta of 25 founding members in December 2025 and still advertises founding membership
  • No direct insurance billing (HSA/FSA reimbursement only)
Treatments offered
EnclomipheneCompounded semaglutideTirzepatideSermorelinSildenafilTadalafilPT-141 (bremelanotide)Oxytocin nasal sprayMetforminNAD+ (injection and nasal spray)Glutathione (injection and nasal spray)GHK-Cu creamTestosterone cypionate
Cancelling

Payment and Refund Policy (updated 2026-07-28): cancel via the option in account settings or by emailing support@onetwenty.com. The annual membership renews automatically. A refund is available only within 7 days of purchase and only if no service has started, minus a 3% fee. After that the annual fee is non-refundable, except for a discretionary prorated refund if no lab is reachable. Medication add-ons are non-refundable once prescribed.

Where it is available

Site FAQ: 'available in 49 states except for Rhode Island'; NY and NJ carry a higher fee ($749/yr) because of state lab-draw rules. DC not mentioned.

#2

People who want frequent, needle-free at-home tracking of a focused biomarker panel and do not need a clinician or prescriptions from the same service.

Starting price
$124 per at-home test kit
Consult model
Unconfirmed
Prescriber
Unconfirmed
Labs
Included
Insurance
Cash pay
Availability
49 states
Cancellation
Self-serve online
Founded
Burlington, MA

Pricing

Homepage (seen 2026-11-05): 'Start testing $124 + Shipping & handling'; 'No monthly fees'; the plan renews on the cadence chosen (monthly, quarterly or every 6 months) and includes the test kit with a choice of four core panels (Longevity Essentials, Thyroid Focus, Hormone Focus, Heart & Metabolic; 25 to 28 biomarkers per test, upgradeable to 59), results dashboard, action plan and AI assistant. Upgrades per test: Ultimate 360 (60 biomarkers) +$125; GLP Optimization panel +$75; IGF-1 add-on +$70. Shipping and handling amount is not stated on the pages loaded. Product data embedded in the pricing page lists the Longevity Essentials kit at $125 per period and a one-time panel at $225; those figures are not displayed as text.

Prices as listed on November 5, 2026. They change often; confirm at checkout.

What we like

  • Each plan period includes an at-home test kit; no lab visit or needle draw
  • Self-serve cancellation in the account portal with no minimum commitment
  • Choice of testing cadence (monthly, quarterly or every 6 months) and free switching between four core panels
  • HSA/FSA eligible

Watch out for

  • Not available in Hawaii or New York; telemedicine excluded in several more states and DC
  • Shipping and handling fee is added to every kit and the amount is not published on the pages loaded
  • No refund once a kit has shipped
  • Wellness-only service: no prescribing, and results come with a recommendation to consult your own physician
Cancelling

FAQ: modify, pause or cancel 'anytime from your account portal. There's no commitment'; prepaid annual plans stop renewing at the end of the period. Terms of Service (last updated 2026-06-15): subscriptions auto-renew until cancelled via the 'Manage Membership' page in Account Settings or by emailing support@siphoxhealth.com. Refund Policy (updated 2026-02-02): no refunds for a period in which a kit has already shipped; to cancel a pending shipment, email support; monthly payments are nonrefundable and benefits continue to the end of the paid period. Kits cannot be returned.

Where it is available

State Coverage page: 'We do not yet provide services in: Hawaii and New York.' Diagnostic kits are offered everywhere else, including DC (48 states + DC). Telemedicine services are excluded in Alaska, Delaware, DC, Hawaii, Kansas, Louisiana, Mississippi and New York. Also offered in Canada without telemedicine.

OneTwenty vs SiPhox Health: common questions

Is OneTwenty or SiPhox Health better?

OneTwenty ranks higher on our rubric (9.9 vs 9.0 out of 10; * means provisional, and fully verified scores rank first). That reflects price transparency, labs, availability, cancellation terms and treatment range, not clinical outcomes. OneTwenty: People who want their blood retested every 90 days (a 101-marker baseline plus three follow-up panels a year) and want custom supplements and prescriptions, at published prices, driven by those results in one membership. SiPhox Health: People who want frequent, needle-free at-home tracking of a focused biomarker panel and do not need a clinician or prescriptions from the same service.

Which is cheaper, OneTwenty or SiPhox Health?

OneTwenty starts at $499/yr membership ($749/yr in NY/NJ); medications $49 to $279/mo extra. SiPhox Health starts at $124 per at-home test kit plus shipping, on a monthly, quarterly or 6-month plan. Compare what each price includes, especially labs and medication.

Do OneTwenty and SiPhox Health include lab work?

OneTwenty: included. SiPhox Health: included.

Which is easier to cancel?

OneTwenty: Payment and Refund Policy (updated 2026-07-28): cancel via the option in account settings or by emailing support@onetwenty.com. The annual membership renews automatically. A refund is available only within 7 days of purchase and only if no service has started, minus a 3% fee. After that the annual fee is non-refundable, except for a discretionary prorated refund if no lab is reachable. Medication add-ons are non-refundable once prescribed. SiPhox Health: FAQ: modify, pause or cancel 'anytime from your account portal. There's no commitment'; prepaid annual plans stop renewing at the end of the period. Terms of Service (last updated 2026-06-15): subscriptions auto-renew until cancelled via the 'Manage Membership' page in Account Settings or by emailing support@siphoxhealth.com. Refund Policy (updated 2026-02-02): no refunds for a period in which a kit has already shipped; to cancel a pending shipment, email support; monthly payments are nonrefundable and benefits continue to the end of the paid period. Kits cannot be returned.

Can OneTwenty or SiPhox Health prescribe treatment?

OneTwenty: yes (Enclomiphene, Compounded semaglutide, Tirzepatide, Sermorelin). SiPhox Health: no, testing and insights only.

Which is available in more states?

OneTwenty: 49 states. SiPhox Health: 49 states.

Sources

Regulatory and primary sources

  1. OneTwenty: OneTwenty homepage and FAQ ↗
  2. OneTwenty: OneTwenty Pricing (prices checked by the company 2026-11-02; seen 2026-11-05) ↗
  3. OneTwenty: OneTwenty Payment and Refund Policy (updated July 28, 2026) ↗
  4. OneTwenty: OneTwenty Longevity Treatments ↗
  5. OneTwenty: OneTwenty Tirzepatide ($279/mo or $749 quarterly) ↗
  6. OneTwenty: OneTwenty Testosterone Cypionate ($99/mo) ↗
  7. OneTwenty: OneTwenty BPC-157 (coming soon) ↗
  8. OneTwenty: OneTwenty What We Test (101-marker baseline; 'Now accepting founding members') ↗
  9. OneTwenty: OneTwenty Press (closed beta announcements) ↗
  10. OneTwenty: OneTwenty Terms of Service (effective August 27, 2026) ↗
  11. OneTwenty: OneTwenty Privacy Policy (effective August 27, 2026) ↗
  12. OneTwenty: Upwork: Physician Advisor (MD/DO), Preventive & Longevity Medicine (search snippet; page returned 403) ↗
  13. OneTwenty: AJMC: 5 things to know about HHS's interim peptide compounding policy (2026-10-29) ↗
  14. OneTwenty: Trustpilot (404, no profile; rechecked 2026-11-05) ↗
  15. SiPhox Health: SiPhox Health homepage (seen 2026-11-05) ↗
  16. SiPhox Health: SiPhox Health FAQ ↗
  17. SiPhox Health: SiPhox Health State Coverage ↗
  18. SiPhox Health: SiPhox Health Refund Policy (updated 2026-02-02) ↗
  19. SiPhox Health: SiPhox Health Terms of Service (last updated 2026-06-15) ↗
  20. SiPhox Health: SiPhox Health panels and upgrade prices ↗
  21. SiPhox Health: SiPhox Longevity Essentials program page ↗
  22. SiPhox Health: SiPhox GLP Optimization panel ↗
  23. SiPhox Health: Intel, Khosla lead $27M in SiPhox Health (TechCrunch, 2023-07-19; search snippet) ↗
  24. SiPhox Health: SiPhox Health on Trustpilot (read 2026-11-05) ↗
  25. Lindy Health clinic scoring rubric ↗