5 Best Peptides for Weight Loss – Reduce Hunger & Lose Belly Fat

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If you’re on a weight loss journey or trying to manage your weight, you may have heard about the benefits of peptides. Peptides are not only great for weight management, but they can also positively impact your overall health.

In this article, we’ll discuss the best peptides for weight loss and how they can help improve your overall health. These peptides have been proven safe and effective for weight management and can be a game-changer in your weight loss journey.

So, let’s explore the world of peptides and how they can help you achieve your weight loss and overall health goals.

Key Takeaways

  • The top 5 peptides for weight loss are CJC-1295, Semaglutide, Tesamorelin, AOD 9604, and 5-Amino 1MQ
  • These peptides help lose weight by promoting lipolysis, reducing lipogenesis, or boosting growth hormone levels
  • Peptides can be an effective and safe addition to a weight loss journey when used under the guidance of a healthcare professional and coupled with a healthy diet and exercise plan

AOD 9604

AOD 9604 is considered one of the best weight loss peptides due to its ability to stimulate fat metabolism, increase fat oxidation, and reduce body fat.

This synthetic peptide is a modified version of the human growth hormone that includes amino acids 176-191.

AOD 9604 works by breaking down fat cells and preventing their formation, resulting in a reduction in body weight and an increase in lean muscle growth [1]. It mimics the natural hormone, human growth hormone, which is known to promote fat oxidation and fat burning.

As one of the most popular weight loss peptides, AOD 9604 is effective in promoting weight loss while preserving muscle mass and is an excellent addition to any weight loss plan. Plus, clinical trials demonstrate AOD 9604 to have a good safety profile and is generally well-tolerated by most individuals – making it a total win-win!


AOD -9604 is a part of the Growth Hormone peptide that is important for the fat loss process. Usually, HGH will cause fat loss while also dumping glycogen into the blood via its mechanism of action.

However, AOD 9604 does not do the latter part because it isn’t the full HGH peptide. It will only cause fat loss.

However, unlike HGH, it will not increase insulin resistance and it will not increase IGF-1 levels either (the latter part is a bummer).

CJC 1295

CJC 1295 is a synthetic peptide for weight loss because it helps to reduce body weight by promoting fat loss and increasing energy production [2]. Stimulating the production of growth hormone in the pituitary gland, it leads to increased fat metabolism, reduced adipose tissue and weight loss.

With many users reporting significant fat loss and improved body composition, CJC 1295 is rapidly gaining popularity amongst individuals looking to lose weight efficiently.

CJC 1295

CJC 1295 is known as a Growth Hormone Releasing Hormone. This will cause the pituitary gland to produce, secrete, and pulsate more Growth Hormone into the bloodstream.

HGH has been linked to increased fat loss through its ability to increase lipolysis. It will also increase IGF-1 levels throughout the body which have been linked to fat loss, muscle gain, bone health, skin health, and even better hair.

You are best taking a GHRH with a GHRP for optimal results.


Semaglutide is a synthetic peptide that works as a glucagon-like peptide-1 (GLP-1) receptor agonist, which regulates insulin secretion and glucose metabolism. It can help reduce appetite, leading to weight loss.

Semaglutide is a popular peptide injection that has also been clinically proven to aid in weight loss by delaying gastric motility and reducing appetite [3].


Semaglutide is a new peptide on the market widely famous for its use in reducing obesity rates. It’s known as a glucagon-like peptide-1 (GLP-1) receptor agonist, and can help with regulating insulin levels in the body.

Once you can regulate insulin levels you are less likely to feel hungry – you eat less and you lose weight. It can also improve glucose metabolism meaning the food that you do eat works a lot better.

It also reduces the rate at which food passes your system, keeping you fuller for longer.


Tesamorelin is a growth hormone-releasing hormone analog that stimulates the production of growth hormone in the pituitary gland. It targets abdominal fat specifically and has been shown to reduce visceral fat in both men and women [4].

This peptide works by stimulating the pituitary gland to produce more growth hormone, which increases fat breakdown and metabolism.



Tesamorelin is known as a Growth Hormone Releasing Hormone (GHRH). A GHRH will cause the pituitary gland to release more Growth Hormone which will have various downstream effects on the body.

Much like CJC it will cause a similar release in GH in the body leading to fat loss and muscle gain. That said, the benefits of Tesamorelin are more geared towards fat loss.

Tesamorelin has been found to be quite good at reducing the amount of fat around the abdomen.

HGH Frag

HGH-FRAG 176-191 is a spliced version or derivative of HGH and is known to trigger lipolytic activity, causee hypoglycemia as well as musculoskeletal strengthening with much less adverse effects compared to its parent compound.

HGH Fragment 176-191

Human growth hormone fragment, aka HGH-FRAG, has lipolytic and hypoglycemic properties. It Increases the formation of beta-3 adrenergic receptors in fatty tissues.

The receptors then increase the utilization and mobilization of fats. Hypoglycemic attributes are found in HGH-FRAG due to the presence of the C-terminal. It also has possible effects on cartilage Regeneration and growth alongside hyaluronic acid.

How do Peptides for Weight Loss work?

Peptides are short chains of amino acids that induce weight loss by the following methods:

  • By targeting specific hormones, enzymes, and receptors in the body that regulate metabolism and fat storage.
  • By increasing the production of hormones such as growth hormone, which boosts metabolism and helps burn fat.
  • By suppressing ghrelin, a hormone that stimulates hunger, and reducing appetite.

Overall, peptides for weight loss can be a safe and effective addition to a weight loss plan when used under the guidance of a healthcare professional.

Best Peptides for Female Weight Loss

When it comes to weight loss, women may face unique challenges due to differences in hormones and metabolism. Luckily, there are peptides that can help women achieve their weight loss goals safely and effectively.

  • HCG: One peptide that has gained popularity among women is HCG, which can promote fat loss and reduce appetite. HCG mimics the hormone produced during pregnancy and can stimulate the metabolism to burn fat for energy.Other peptides for female weight loss include:
  • Tesamorelin: This peptide has been found to reduce visceral fat in women, which is the dangerous fat that accumulates around organs and increases the risk of health issues such as heart disease and diabetes.
  • Ipamorelin and CJC-1295: These peptides help women build lean muscle mass while promoting fat loss and improving overall body composition. They can also enhance energy levels and improve sleep, which are critical for weight loss.

Overall, the best peptides for female weight loss depend on individual needs and health goals. Consulting with a healthcare professional can help determine the best peptide therapy plan for each woman’s unique needs.

Side Effects of HCG 

While HCG peptides can be effective in aiding weight loss in women, they can also have some potential side effects including:

  • Headaches
  • Irritability
  • Fatigue
  • Breast tenderness and swelling due to its estrogen-mimicking effects
  • In rare cases, HCG use can lead to ovarian hyperstimulation syndrome (OHSS), which is characterized by enlarged ovaries and can cause abdominal pain, nausea, and vomiting

Results of AOD 9604

In the Reddit thread ‘anyone tried AOD9604? If so any good results?’, the below results were reported:  

“Yes! Awesome results. I started with 10 bottles and notice significant weight loss and fat loss”

Reddit Username MattyT1978

“Did not do much. IMO tesamorelin or even ipa/cjc are way more effective. As another poster eluded to, I am insulin resistant and it was not game changing for me at all even when used in a stack with other peps”

Reddit Username MakoombaMagmby

In a Nutshell

In conclusion, peptides can be a powerful tool for weight loss when used appropriately. Consult with a healthcare professional to determine the best peptide therapy plan for your unique needs and weight goals. Keep calm and peptide on!

People Also Ask

Do peptides really work for weight loss?

While peptides can be a useful addition to your weight loss journey, their effectiveness is greatly enhanced when combined with a healthy diet and regular exercise routine. If you’re already making healthy lifestyle choices but are still struggling to lose weight, peptides may be the missing piece of the puzzle to help you reach your goals.

How much weight do you lose on peptides?

When combined with a healthy diet and lifestyle, peptide therapy can help clients lose a significant amount of weight, ranging from 60 to 75 pounds.

How fast do you see results from peptides?

Peptide therapy typically requires a “loading” period of 3-6 months before its full effects can be noticed. However, some benefits may be observed within the first few weeks and can increase significantly with continued therapy.

Is it safe to use peptides everyday?

The safety of using peptides daily depends on the specific peptide, the dose, and the individual’s health status. While some peptides may be safe for daily use, others may require more caution and careful monitoring. It’s important to work with a healthcare professional to determine the appropriate dose and frequency of use for each peptide and to monitor for any potential side effects.


News, Medical and Life Sciences, Obesity drug codenamed AOD 9604 highly successful in trials, 16 December 2004. https://www.news-medical.net/news/2004/12/16/6878.aspx

Teichman SL, Neale A, Lawrence B, Gagnon C, Castaigne JP, Frohman LA. Prolonged stimulation of growth hormone (GH) and insulin-like growth factor I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006 Mar;91(3):799-805. doi: 10.1210/jc.2005-1536. Epub 2005 Dec 13. PMID: 16352683. https://pubmed.ncbi.nlm.nih.gov/16352683/

Christou GA, Katsiki N, Blundell J, Fruhbeck G, Kiortsis DN. Semaglutide as a promising antiobesity drug. Obes Rev. 2019 Jun;20(6):805-815. doi: 10.1111/obr.12839. Epub 2019 Feb 15. PMID: 30768766. https://pubmed.ncbi.nlm.nih.gov/30768766/

Falutz J, Mamputu JC, Potvin D, Moyle G, Soulban G, Loughrey H, Marsolais C, Turner R, Grinspoon S. Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data. J Clin Endocrinol Metab. 2010 Sep;95(9):4291-304. doi: 10.1210/jc.2010-0490. Epub 2010 Jun 16. PMID: 20554713. https://pubmed.ncbi.nlm.nih.gov/20554713/

Watowich, Stanley J. Discovery of Novel N-Nicotinamide Methyltransferase Inhibitors to Combat Obesity-Linked Osteoarthritis and Metabolic Disease Among Veterans and Beneficiaries (2018). https://apps.dtic.mil/sti/citations/AD1044339

Junichi I. et al, Growth hormone secretagogues: history, mechanism of action, and clinical development, JSCM Rapid Communications Vol. 3 Issue 1, 09 February 2020.https://onlinelibrary.wiley.com/doi/full/10.1002/rco2.9

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